Karen Lee Henderson, age 74 of Brookport, Illinois passed away at 11:02 pm on Wednesday, October 22, 2025 at Baptist Health Paducah.

Visitation will be held on Monday, October 27, 2025 from 2 pm to 5 pm at the Loftus-McManus Brookport Funeral Home.

Karen is survived by her children, Jennifer Henderson, Wanda Stewart and husband Scott, James Hall and wife Tiffany, Eric Martin and wife Amanda, Steven Sikes and wife Melissa, and Amanda Cooper and husband Brent; 16 grandchildren; 18 great grandchildren; sisters, Arema Hinkle, Wanda Giasson, and Patricia Harvill; brothers, David Henderson and Richard Henderson; several nieces and nephews.

Karen was preceded in death by her parents, Russell and Loretta (Lawbaugh) Henderson; sisters, Nedra Henderson, Virginia Garrity, Lois Henderson, and Carol Studley; brother, Norman Henderson.

Arrangements have been entrusted to Loftus-McManus Brookport Funeral Home. Online condolences may be made at www.aikinsfarmer-millerfh.com